Common Abbreviations in Peptide Science

Abbreviation Full Name
AAA Amino Acid Analysis
ACN Acetonitrile
API Active Pharmaceutical Ingredient
Boc tert-Butyloxycarbonyl
cAMP Cyclic Adenosine Monophosphate
CAPA Corrective and Preventive Action
CAS Chemical Abstracts Service
CoA/COA Certificate of Analysis
CQA Critical Quality Attribute
DCM Dichloromethane
DIEA N,N-Diisopropylethylamine
DMF Dimethylformamide
DMSO Dimethyl Sulfoxide
DPP-4 Dipeptidyl Peptidase-4
EOP End-of-Product
ESI Electrospray Ionization
Fmoc 9-Fluorenylmethoxycarbonyl
GHS Globally Harmonized System
GLP Good Laboratory Practice
GLP-1 Glucagon-Like Peptide-1
GMP Good Manufacturing Practice
GPCR G Protein-Coupled Receptor
HBTU Hexafluorophosphate Benzotriazole Tetramethyl Uronium
HFIP Hexafluoroisopropanol
HOBt Hydroxybenzotriazole
HPLC High-Performance Liquid Chromatography
IACUC Institutional Animal Care and Use Committee
ICH International Council for Harmonisation
IPC In-Process Control
LAL Limulus Amebocyte Lysate
LC-MS Liquid Chromatography-Mass Spectrometry
LOD Limit of Detection
LOQ Limit of Quantification
MALDI-TOF Matrix-Assisted Laser Desorption/Ionization Time-of-Flight
MOQ Minimum Order Quantity
MS Mass Spectrometry
MW Molecular Weight
NMP N-Methylpyrrolidone
NMT Not More Than
NLT Not Less Than
PBS Phosphate-Buffered Saline
PEG Polyethylene Glycol
pI Isoelectric Point
QC Quality Control
QA Quality Assurance
QbD Quality by Design
RH Relative Humidity
RP-HPLC Reversed-Phase High-Performance Liquid Chromatography
RSD Relative Standard Deviation
RT Retention Time
SDS Safety Data Sheet
SPPS Solid-Phase Peptide Synthesis
TDS Technical Data Sheet
TFA Trifluoroacetic Acid
TIS Triisopropylsilane
TOC Table of Contents
UPLC Ultra-Performance Liquid Chromatography
UV Ultraviolet
WFI Water for Injection