KPV Peptide — Product Introduction & Overview¶
1.1 Product Identity¶
| Field | Value |
|---|---|
| Product Name | KPV Peptide |
| Sequence | Lys-Pro-Val |
| Systematic Name | L-Lysyl-L-prolyl-L-valine |
| CAS Number | 67727-97-3 |
| Molecular Formula | C16H30N4O4 |
| Molecular Weight | 342.44 Da |
| Product Type | Synthetic tripeptide; α-MSH (11-13) C-terminal fragment |
| Document ID | RPL-TM-KPV-001 |
| Publisher | RPL Peptide (Qingdao RPL Biotechnology Co., Ltd.) |
1.2 Background¶
KPV (Lys-Pro-Val) is a naturally occurring tripeptide corresponding to the C-terminal fragment (amino acid residues 11-13) of alpha-melanocyte-stimulating hormone (α-MSH). Although small in size—just three amino acids—KPV retains several key bioactive properties of its parent molecule α-MSH, most notably anti-inflammatory and immunomodulatory activities.
The peptide was first identified and characterized in studies investigating the structure-activity relationship of α-MSH fragments. Researchers discovered that the C-terminal tripeptide Lys-Pro-Val was sufficient to mediate certain anti-inflammatory effects without requiring the full 13-amino-acid melanocortin peptide.
1.3 Scientific Significance¶
KPV has attracted research interest across multiple biomedical fields:
- Inflammation Research: KPV demonstrates anti-inflammatory activity through modulation of cytokine production (TNF-α, IL-1β, IL-6) and NF-κB pathway regulation.
- Gastrointestinal Studies: Investigated for protective effects in models of colitis and intestinal inflammation.
- Wound Healing: Studied for potential roles in tissue repair and regeneration, particularly in models of inflammatory bowel disease and skin wounds.
- Ocular Research: Evaluated for anti-inflammatory properties in corneal and conjunctival inflammation models.
- Dermatological Applications: Research into melanocortin-derived peptide activity on skin cells.
1.4 Mechanism of Action (Research Findings)¶
Published studies indicate KPV exerts its biological effects through multiple proposed mechanisms:
- Melanocortin Receptor Modulation: Although KPV has lower affinity than full-length α-MSH, it is believed to interact with melanocortin receptors (MC1R, MC3R, MC4R, MC5R) depending on cellular context.
- NF-κB Pathway Inhibition: KPV has been shown to suppress NF-κB activation, leading to reduced pro-inflammatory cytokine expression.
- Anti-Oxidant Activity: The peptide may upregulate heme oxygenase-1 (HO-1) and other cytoprotective enzymes.
- Cytokine Regulation: Suppression of TNF-α, IL-1β, and IL-6 in activated macrophages and epithelial cells.
1.5 Research Applications¶
| Research Area | Application |
|---|---|
| Immunology | Cytokine modulation, macrophage polarization studies |
| Gastroenterology | Colitis models, intestinal barrier function |
| Dermatology | Skin inflammation, wound healing models |
| Ophthalmology | Corneal inflammation, dry eye disease models |
| Neuroinflammation | Microglial activation, neuroprotection |
| Sepsis Models | Systemic inflammatory response modulation |
1.6 Scope of This Manual¶
This technical manual provides comprehensive documentation for researchers, procurement professionals, and quality assurance teams using KPV Peptide in laboratory settings. Contents include:
- Chemical and physical property data
- Synthesis and manufacturing specifications
- Analytical methods and quality control protocols
- Safety data and handling guidelines
- Reconstitution and storage recommendations
- Certificates and regulatory documentation
1.7 Intended Use¶
KPV Peptide is intended for laboratory research use only. It is not for diagnostic, therapeutic, or veterinary use, nor for human consumption.
Document ID: RPL-TM-KPV-001 | Section 1/18 | Version 1.0 | July 2026