Motsc overview
Chapter 01: Product Overview¶
1.1 Introduction¶
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the mitochondrial 12S rRNA gene. It belongs to the family of mitochondrial-encoded peptides that mediate inter-organellar communication and regulate metabolic homeostasis. MOTS-C has garnered significant research interest for its roles in metabolic regulation, exercise physiology, insulin sensitivity, and age-related metabolic decline.
Unlike nuclear-encoded peptides, MOTS-C is transcribed and translated within the mitochondria, a unique biosynthetic origin that positions it as a mitochondrial signaling molecule capable of translocating to the nucleus under cellular stress conditions (e.g., glucose restriction, AMPK activation) to regulate gene expression.
1.2 Product Identification¶
| Parameter | Specification |
|---|---|
| Product Name | MOTS-C (Mitochondrial-Derived Peptide) |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2,174.62 Da |
| Peptide Length | 16 amino acids |
| Sequence | MRWQEMGYIFYPRKLR |
| Type | Linear synthetic peptide |
| Isoelectric Point (pI) | ~11.3 (basic) |
| Net Charge at pH 7.4 | +3 (positive) |
1.3 Product Specifications¶
| Attribute | Standard |
|---|---|
| Purity | ≥98% (HPLC, 214 nm) |
| Appearance | White to off-white lyophilized powder |
| Packaging | 10 mg, 20 mg, 40 mg per vial |
| Box Contents | 10 vials per box |
| Pricing Range | $68–$196 per box (varies by quantity and packaging) |
| Storage | 2–8 °C (short-term, ≤6 months); –20 °C (long-term, ≥12 months) |
| Shelf Life | 24 months when stored at –20 °C |
| Solubility | Soluble in water, PBS, and saline |
1.4 Classification¶
- Molecular Class: Mitochondrial-derived peptide (MDP)
- Gene Origin: MT-RNR2 (12S rRNA gene)
- Therapeutic Research Areas: Metabolic syndrome, type 2 diabetes, obesity, sarcopenia, NAD⁺ metabolism, exercise mimetics, aging research
- Regulatory Status: For laboratory research use only. Not for human or veterinary therapeutic use.
1.5 Manufacturer Information¶
RPL Peptide Qingdao RPL Biotechnology Co., Ltd. Official Website: https://rplpeptides.com
RPL Peptide is a professional manufacturer and supplier of high-purity synthetic peptides for research purposes. All products are manufactured under controlled laboratory conditions and subjected to rigorous quality control (QC) testing including HPLC, LC-MS, and UPLC analysis. Each batch is accompanied by a Certificate of Analysis (COA).
1.6 Related Documents¶
| Document | Description |
|---|---|
| RPL-TM-MOT-001 | Complete Technical Documentation Manual (this document) |
| RPL-TM-MOT-001-COA | Certificate of Analysis |
| RPL-TM-MOT-001-SDS | Safety Data Sheet |
| RPL-TM-MOT-001-MS | Mass Spectrometry Analysis Report |
| RPL-TM-MOT-001-HPLC | HPLC Chromatogram Report |
End of Chapter 01 — Product Overview
Document ID: RPL-TM-MOT-001 | Chapter 01 | Version 1.0 | July 2026 Publisher: RPL Peptide (Qingdao RPL Biotechnology Co., Ltd.)